Abstract Histone H3 lysine 9 (H3K9) methylation is a conserved modification that generally
represses transcription. In Caenorhabditis elegans it is enriched on silent tissue-specific …

The developmental role of histone H3K9 methylation (H3K9me), which typifies
heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a …

Variation in patterns of methylations of histone tails reflects and modulates chromatin
structure and function. To provide a framework for the analysis of chromatin function in …

Caenorhabditis elegans has two histone H3 Lys9 methyltransferases, MET-2 (SETDB1
homolog) and SET-25 (G9a/SUV39H1 related). In worms, we found simple repeat …

Exogenous double-stranded RNA (dsRNA) has been shown to exert homology-dependent
effects at the level of both target mRNA stability and chromatin structure. Using C. elegans …

Heterochromatin, typically marked by histone H3 trimethylation at lysine 9 (H3K9me3) or
lysine 27 (H3K27me3), represses different protein-coding genes in different cells, as well as …

A dynamic epigenome is critical for appropriate gene expression in development and
health,,,–. Central to this is the intricate process of transcription,,,,–, which integrates cellular …

Eukaryotic genomes are organized into domains of differing structure and activity. There is
evidence that the domain organization of the genome regulates its activity, yet our …

Histone methylation is a prominent feature of eukaryotic chromatin that modulates multiple
aspects of chromosome function. Methyl modification can occur on several different amino …

In C. elegans, alterations to chromatin produce transgenerational effects, such as inherited
increase in lifespan and gradual loss of fertility. Inheritance of histone modifications can be …