Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
A Mahajan, CN Spracklen, W Zhang, MCY Ng… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
DIAbetes Genetics Replication And Meta-analysis … - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …
aggregated published meta-analyses of genome-wide association studies (GWAS) …
[HTML][HTML] Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
N Genet - Nat Genet, 2014 - ncbi.nlm.nih.gov
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …
aggregated published meta-analyses of genome-wide association studies (GWAS) …
Type 2 diabetes: genetic data sharing to advance complex disease research
J Flannick, JC Florez - Nature Reviews Genetics, 2016 - nature.com
As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …
experimental characterization have for years formed a paradigm for identifying genes or …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
[PDF][PDF] Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom∼ 50,000 SNP genotyping array (the ITMAT-Broad-CARe …
meta-analyses by using a custom∼ 50,000 SNP genotyping array (the ITMAT-Broad-CARe …
An expanded genome-wide association study of type 2 diabetes in Europeans
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency
spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D …
spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D …
Genome-wide association studies and type 2 diabetes
In recent years, the search for genetic determinants of type 2 diabetes (T2D) has changed
dramatically. Although linkage and small-scale candidate gene studies were highly …
dramatically. Although linkage and small-scale candidate gene studies were highly …
Genome-wide association studies in type 2 diabetes
MI McCarthy, E Zeggini - Current diabetes reports, 2009 - Springer
Despite numerous candidate gene and linkage studies, the field of type 2 diabetes (T2D)
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …
[HTML][HTML] Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However,
little is known about the genetic risk in African Americans despite the recent identification of …
little is known about the genetic risk in African Americans despite the recent identification of …