An updated inventory of about 150 human DNA repair genes is described. The compilation
includes genes encoding DNA repair enzymes, some genes associated with cellular …

DNA repair systems are essential for the maintenance of genome integrity. Consequently,
the disregulation of repair genes can be expected to be associated with significant …

DNA repair systems act to maintain genome integrity in the face of replication errors,
environmental insults, and the cumulative effects of age. More than 70 human genes directly …

DNA Repair Mechanisms is an account of the proceedings at a major international
conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The …

The ability to recognize and repair abnormal DNA structures is common to all forms of life.
Studies in a variety of species have identified an incredible diversity of DNA repair …

DNA repair is an important molecular defense system against agents that cause cancer,
degenerative diseases, and aging. Several repair systems in humans protect the genome by …

The history of the repair of damaged DNA can be traced to the mid-1930s. Since then
multiple DNA repair mechanisms, as well as other biological responses to DNA damage …

Cellular genomes are vulnerable to an array of DNA-damaging agents, of both endogenous
and environmental origin. Such damage occurs at a frequency too high to be compatible …

Cellular DNA is subjected to continual attack, both by reactive species inside cells and by
environmental agents. Toxic and mutagenic consequences are minimized by distinct …

The repair of damaged DNA requires the function of multiple proteins in generally damage-
specific, nonredundant pathways. The relationship of DNA repair to cancer susceptibility is …