It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes
injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a …

The blood–brain barrier (BBB) is one of the most selective endothelial barriers. An
understanding of its cellular, morphological, and biological properties in health and disease …

The blood-brain barrier (BBB) is a dynamic barrier essential for maintaining the
microenvironment of the brain. Although the special anatomical features of the BBB …

The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …

Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …

The blood–brain barrier (BBB) plays a key role in regulating transport into and out of the
brain. With increasing interest in the role of the BBB in health and disease, there have been …

The blood-brain barrier (BBB) is the interface between the vasculature and the brain,
regulating molecular and cellular transport into the brain. Endothelial cells (ECs) that form …

The blood-brain barrier (BBB) poses a serious impediment to the delivery of effective
therapies to the central nervous system (CNS). Over time, various model systems have been …

Highlights•Various approaches exist to recreate 2D and 3D structures of the
BBB.•Quantitative barrier functions in some BBB-chips are comparable to in vivo …

Barriers are the hallmark of a healthy physiology, blood-brain barrier (BBB) being a tough
nut to crack for most of the antigens and chemical substances. The presence of tight …