Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

Membrane flow through the cell is a highly dynamic process in which intracellular
compartments communicate via tubulo-vesicular structures shuttling cargo molecules to their …

Rab proteins compose the largest family of small GTPases and control the different steps of
intracellular membrane traffic. More recently, they have been shown to also regulate cell …

Rab GTPases control intracellular membrane traffic by recruiting specific effector proteins to
restricted membranes in a GTP-dependent manner. In this Cell Science at a Glance and the …

Endocytosis is characterized by vesicular transport along numerous pathways. Common
steps in each pathway include membrane budding to form vesicles, transport to a particular …

Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …

Highlights•Rab GTPases recruit distinct sets of effector proteins to membrane
microdomains.•Rab-bound effectors confer unique functionalities to membrane …

Summary The Rab GTPases recruit peripheral membrane proteins to intracellular
organelles. These Rab effectors typically mediate the motility of organelles and vesicles and …

In all eukaryotic organisms, Rab GTPases function as critical regulators of membrane traffic,
organelle biogenesis and maturation, and related cellular processes. The numerous Rab …