Vascularization and efficient perfusion are long-standing challenges in cardiac tissue
engineering. Here we report engineered perfusable microvascular constructs, wherein …

Highlights•Tissue engineering approaches have generated blood vessels in clinical
trials.•Challenges remain to build perfusable microvasculature for implantation.• …

Arterial bypass grafts remain the gold standard for the treatment of end-stage ischaemic
disease. Yet patients unable to tolerate the cardiovascular stress of arterial surgery or those …

The primary function of vascular networks is to transport blood and deliver oxygen and
nutrients to tissues, which occurs at the interface of the microvasculature. Therefore, the …

We demonstrate here a cardiac tissue-engineering strategy addressing multicellular
organization, integration into host myocardium, and directional cues to reconstruct the …

Rationale Perfusion decellularization of cadaveric hearts removes cells and generates a cell-
free extracellular matrix scaffold containing acellular vascular conduits, which are …

Myocardial infarction (MI) causes significant cell loss and damage to myocardium. Cell-
based therapies for treatment of MI aim to remuscularize the resultant scar tissue, but the …

Functional and perfusable vascular network formation is critical to ensure the long-term
survival and functionality of engineered tissues after their transplantation. Although several …

Cardiac tissue engineering aims to produce replacement tissue patches in the lab to replace
or treat infarcted myocardium. However, current patches lack preformed …

Pre-vascularization is important for the reconstruction of dense and metabolically active
myocardial tissue and its integration with the host myocardium after implantation. Herein, we …