Abstract Background Messenger RNA (mRNA) has gained remarkable attention as an
alternative to DNA-based therapies in biomedical research. A variety of biodegradable …

Messenger RNA (mRNA)-based therapy shows immense potential for broad biomedical
applications. However, the development of safe and efficacious mRNA delivery vectors …

As an appealing alternative to treat and prevent diseases ranging from cancer to COVID-19,
mRNA has demonstrated significant clinical effects. Nanotechnology facilitates the …

RNA and DNA delivery technologies using lipid nanoparticles (LNPs) have advanced
significantly, as demonstrated by their successful application in mRNA vaccines. To date …

In recent years, in vitro transcribed messenger RNA (mRNA) has emerged as a potential
therapeutic platform. To fulfill its promise, effective delivery of mRNA to specific cell types …

Abstract mRNA based gene therapies hold the potential to treat multiple diseases with
significant advantages over DNA based therapies, including rapid protein expression and …

Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made
of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids. The …

Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles
that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …

Messenger RNA-based vaccines have the potential to trigger robust cytotoxic immune
responses, which are essential for fighting cancer and infectious diseases like HIV. Dendritic …

Abstract Introduction Lipid based nanoparticles (LNPs) are clinically successful vectors for
hepatic delivery of nucleic acids. These systems are being developed for non-hepatic …