[HTML][HTML] Aryl hydrocarbon receptor role in co-ordinating SARS-CoV-2 entry and symptomatology: linking cytotoxicity changes in COVID-19 and cancers; modulation by …

G Anderson, A Carbone, G Mazzoccoli - Biology, 2020 - mdpi.com
There is an under-recognized role of the aryl hydrocarbon receptor (AhR) in co-ordinating
the entry and pathophysiology of the severe acute respiratory syndrome-coronavirus-2 …

[HTML][HTML] Hypothesis: Emerging roles for aryl hydrocarbon receptor in orchestrating CoV-2-related inflammation

T Guarnieri - Cells, 2022 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the pathogenic agent
of Coronavirus-Induced Disease-2019 (COVID-19), a multi-organ syndrome which primarily …

[HTML][HTML] SARS-CoV-2-induced lung pathology: AHR as a candidate therapeutic target

F Giovannoni, FJ Quintana - Cell Research, 2021 - nature.com
The aryl hydrocarbon receptor (AHR) is activated by multiple viruses to evade the host
immune response, a strategy exploited in pre-clinical models to limit the replication of Zika …

Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target

J Shi, T Du, J Wang, C Tang, M Lei, W Yu, Y Yang… - Science …, 2023 - science.org
The emergence of a series of SARS-CoV-2 variants has necessitated the search for broad-
spectrum antiviral targets. The aryl hydrocarbon receptor (AhR) senses tryptophan …

[HTML][HTML] A potential role for AHR in SARS-CoV-2 pathology

F Giovannoni, Z Li, CC Garcia, FJ Quintana - Research Square, 2020 - ncbi.nlm.nih.gov
Coronavirus infection is associated to life-threatening respiratory failure. The aryl
hydrocarbon receptor (AHR) was recently identified as a host factor for Zika and dengue …

Aryl hydrocarbon receptor activation ameliorates acute respiratory distress syndrome through regulation of Th17 and Th22 cells in the lungs

BL Holloman, A Cannon, K Wilson, P Nagarkatti… - MBio, 2023 - Am Soc Microbiol
Acute respiratory distress syndrome (ARDS) is triggered by a variety of insults, including
bacterial and viral infections, and this leads to high mortality. While the role of the aryl …

[HTML][HTML] AHR signaling is induced by infection with coronaviruses

F Giovannoni, Z Li, F Remes-Lenicov… - Nature …, 2021 - nature.com
Coronavirus infection in humans is usually associated to respiratory tract illnesses, ranging
in severity from mild to life-threatening respiratory failure. The aryl hydrocarbon receptor …

[HTML][HTML] Tryptophan metabolites and aryl hydrocarbon receptor in severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2) pathophysiology

G Anderson, A Carbone, G Mazzoccoli - International journal of molecular …, 2021 - mdpi.com
The metabolism of tryptophan is intimately associated with the differential regulation of
diverse physiological processes, including in the regulation of responses to severe acute …

[HTML][HTML] AhR and IDO1 in pathogenesis of Covid-19 and the “Systemic AhR Activation Syndrome:” a translational review and therapeutic perspectives

WA Turski, A Wnorowski, GN Turski… - Restorative …, 2020 - content.iospress.com
Covid-19 is the acute illness caused by SARS-CoV-2 with initial clinical symptoms such as
cough, fever, malaise, headache, and anosmia. After entry into cells, corona viruses (CoV) …

[HTML][HTML] Canine coronavirus activates aryl hydrocarbon receptor during in vitro infection

C Cerracchio, F Serra, MG Amoroso, F Fiorito - Viruses, 2022 - mdpi.com
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that interacts
with substrates, including microbial metabolites. Recent advances reveal that AhR is …