MicroRNAs (miRNAs) are genomically encoded small RNAs that hybridize with messenger
RNAs, resulting in degradation or translational inhibition of targeted transcripts. The …

Although hundreds of evolutionarily conserved microRNAs have been discovered, the
functions of most remain unknown. Here, we describe the embryonic spatiotemporal …

Gradients of signalling and transcription factors govern many aspects of embryogenesis,
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …

Understanding the molecular mechanisms that regulate cellular proliferation and
differentiation is a central theme of developmental biology. MicroRNAs (miRNAs) are a class …

MicroRNAs (miRNAs) are regulators of myriad cellular events, but evidence for a single
miRNA that can efficiently differentiate multipotent stem cells into a specific lineage or …

microRNA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA. Most
mammalian genomes contain two copies of miR-1, and in mice, deletion of a single locus …

MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regulate
the expression of proteins generated from messenger RNA transcripts. The in vivo …

Deciphering the mechanisms underlying skeletal muscle-cell differentiation in mammals is
an important challenge. Cell differentiation involves complex pathways regulated at both …

MicroRNAs play important roles in many cell processes, including the differentiation process
in several different lineages. For example, microRNAs can promote differentiation by …

MicroRNAs (miRNAs) negatively regulate gene expression at the post‐transcriptional level,
primarily by base‐pairing with the 3′‐untranslated region (3′‐UTR) of their target mRNAs …