Objectives To evaluate the impact of a functional genetic variant in the natriuretic peptide
clearance receptor, NPR3, on circulating natriuretic peptides (NPs) and myocardial structure …

Background—The primary role of natriuretic peptide receptor-3 (NPR3) or NPR-C is in the
clearance of natriuretic peptides that play an important role in modulating intravascular …

Objective Abnormalities in the natriuretic peptide system could play a key role in the genesis
of hypertension. We evaluated the associations between a family history of hypertension …

Background: B-type natriuretic peptide levels are associated with left ventricular end-
diastolic pressure (LVEDP) and patient outcomes. There is documented variation in the …

Background C-type natriuretic peptide (CNP) is a known target for promoting growth and has
been implicated as a therapeutic opportunity for the prevention and treatment of …

Background: Human genetic variation in the NPR1 (natriuretic peptide receptor 1 gene,
encoding NPR-A, atrial natriuretic peptide receptor 1) was recently shown to affect blood …

The natriuretic peptide (NP) system is a critical physiologic pathway in heart failure with wide
individual variability in functioning. We investigated the genetic component by testing the …

Polymorphisms within individual natriuretic peptide genes have been associated with risk
factors for cardiovascular disease, but their association with clinical outcomes was …

Aims: To analyse the contribution of recently described genetic polymorphisms in the human
natriuretic peptide receptor (NPR‐A) to the interindividual variability in the BNP system …

Genetic susceptibility to common conditions, such as essential hypertension and cardiac
hypertrophy, is probably determined by various combinations of small quantitative changes …