[HTML][HTML] PTEN: multiple functions in human malignant tumors
M Milella, I Falcone, F Conciatori, U Cesta Incani… - Frontiers in …, 2015 - frontiersin.org
PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
PTEN function: how normal cells control it and tumour cells lose it
NR Leslie, CP Downes - Biochemical Journal, 2004 - portlandpress.com
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …
PTEN function in normal and neoplastic growth
LML Chow, SJ Baker - Cancer letters, 2006 - Elsevier
The PTEN tumor suppressor is a central negative regulator of the PI3K/AKT signaling
cascade that influences multiple cellular functions including cell growth, survival …
cascade that influences multiple cellular functions including cell growth, survival …
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
[HTML][HTML] PTEN tumor-suppressor: the dam of stemness in cancer
F Luongo, F Colonna, F Calapà, S Vitale, ME Fiori… - Cancers, 2019 - mdpi.com
PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
[HTML][HTML] Tenets of PTEN tumor suppression
Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …
PTEN proteoforms in biology and disease
Proteoforms are specific molecular forms of protein products arising from a single gene that
possess different structures and different functions. Therefore, a single gene can produce a …
possess different structures and different functions. Therefore, a single gene can produce a …
The role of PTEN signaling perturbations in cancer and in targeted therapy
M Keniry, R Parsons - Oncogene, 2008 - nature.com
The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
Regulation and modulation of PTEN activity
E Naderali, AA Khaki, JS Rad, A Ali-Hemmati… - Molecular biology …, 2018 - Springer
PTEN (Phosphatase and tensin homolog deleted on chromosome ten) is a tumor
suppressor that is frequently mutated in most human cancers. PTEN is a lipid and protein …
suppressor that is frequently mutated in most human cancers. PTEN is a lipid and protein …