mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis
J Pan, Y Xie, H Li, X Li, J Chen, X Liu, J Zhou, X Tang… - Molecular Therapy, 2022 - cell.com
The pathogenesis of acute kidney injury (AKI) is still not fully understood, and effective
interventions are lacking. Here, we explored whether methyltransferase 3 (METTL3) was …
interventions are lacking. Here, we explored whether methyltransferase 3 (METTL3) was …
METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation
F Meng, Y Liu, Q Chen, Q Ma, S Gu… - American Journal …, 2020 - journals.physiology.org
To investigate the mechanism of renal ischemia-reperfusion injury (IRI) via regulation of N 6-
methyl-adenosine (m6A) and relevant genes, IRI was induced in Sprague-Dawley rats, and …
methyl-adenosine (m6A) and relevant genes, IRI was induced in Sprague-Dawley rats, and …
The N6‐methyladenosine mRNA methylase METTL14 promotes renal ischemic reperfusion injury via suppressing YAP1
Y Xu, XD Yuan, JJ Wu, RY Chen, L Xia… - Journal of cellular …, 2020 - Wiley Online Library
Renal ischemia‐reperfusion injury (IRI) is one of the most common causes of acute kidney
injury (AKI), which is closely related to high morbidity and mortality. However, the …
injury (AKI), which is closely related to high morbidity and mortality. However, the …
c-MYC-induced long noncoding RNA MEG3 aggravates kidney ischemia–reperfusion injury through activating mitophagy by upregulation of RTKN to trigger the Wnt/β …
D Liu, Y Liu, X Zheng, N Liu - Cell death & disease, 2021 - nature.com
Abstract Ischemia–reperfusion injury (IRI)-induced acute kidney injury (AKI) is a life-
threatening disease. The activation of mitophagy was previously identified to play an …
threatening disease. The activation of mitophagy was previously identified to play an …
Long non-coding RNA H19 augments hypoxia/reoxygenation-induced renal tubular epithelial cell apoptosis and injury by the miR-130a/BCL2L11 pathway
Y Yuan, X Li, Y Chu, G Ye, L Yang, Z Dong - Frontiers in Physiology, 2021 - frontiersin.org
Acute kidney injury (AKI) is a severe kidney disease defined by partial or abrupt loss of renal
function. Emerging evidence indicates that non-coding RNAs (ncRNAs), particularly long …
function. Emerging evidence indicates that non-coding RNAs (ncRNAs), particularly long …
LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis
J Liu, X Li, J Yang, D Zhang - Apoptosis, 2022 - Springer
Although previous studies have revealed that long noncoding RNAs (lncRNAs) regulate the
progression of ischemic acute kidney injury (AKI), the exact role and mechanism of lncRNA …
progression of ischemic acute kidney injury (AKI), the exact role and mechanism of lncRNA …
MiR-181d-5p targets KLF6 to improve ischemia/reperfusion-induced AKI through effects on renal function, apoptosis, and inflammation
Y Zhang, C Li, C Guan, B Zhou, L Wang… - Frontiers in …, 2020 - frontiersin.org
Renal tubular epithelial cell (RTEC) death and renal interstitial inflammation are the most
crucial pathophysiological changes in acute kidney ischemia/reperfusion injury (IRI). The …
crucial pathophysiological changes in acute kidney ischemia/reperfusion injury (IRI). The …
Long non-coding RNA LRNA9884 promotes acute kidney injury via regulating NF-kB-mediated transcriptional activation of MIF
Y Zhang, PMK Tang, Y Niu, CA García Córdoba… - Frontiers in …, 2020 - frontiersin.org
Acute kidney injury (AKI) is one of the most common complications affecting hospitalized
patients associated with an extremely high mortality rate. However, the underlying …
patients associated with an extremely high mortality rate. However, the underlying …
Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms
J Wang, F Wang, J Ke, Z Li, C Xu, Q Yang… - Science Translational …, 2022 - science.org
The role of N 6-methyladenosine (m6A) modifications in renal diseases is largely unknown.
Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose …
Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose …
LINC00520 targeting miR‐27b‐3p regulates OSMR expression level to promote acute kidney injury development through the PI3K/AKT signaling pathway
X Tian, Y Ji, Y Liang, J Zhang, L Guan… - Journal of Cellular …, 2019 - Wiley Online Library
Background Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm
the kidney. However, the current medical methods have limited therapeutic effects. The …
the kidney. However, the current medical methods have limited therapeutic effects. The …