Genetic epidemiology and insights into interactive genetic and environmental effects in autism spectrum disorders

YS Kim, BL Leventhal - Biological psychiatry, 2015 - Elsevier
Understanding the pathogenesis of neurodevelopmental disorders has proven to be
challenging. Using autism spectrum disorder (ASD) as a paradigmatic neurodevelopmental …

[HTML][HTML] The role of epigenetic change in autism spectrum disorders

YJ Loke, AJ Hannan, JM Craig - Frontiers in neurology, 2015 - frontiersin.org
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental
disorders characterized by problems with social communication, social interaction, and …

Autism and environmental genomics

MR Herbert, JP Russo, S Yang, J Roohi, M Blaxill… - Neurotoxicology, 2006 - Elsevier
Autism spectrum disorders (ASD) are defined by behavior and diagnosed by clinical history
and observation but have no biomarkers and are presumably, etiologically and biologically …

Genetics and genomics of autism spectrum disorder: embracing complexity

S De Rubeis, JD Buxbaum - Human molecular genetics, 2015 - academic.oup.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by
impairments in social communication and social interaction and the presence of repetitive …

[HTML][HTML] Genetic architecture of autism spectrum disorder: Lessons from large-scale genomic studies

L Choi, JY An - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic
component. Recently developed genomic technologies, including microarray and next …

Gene× Environment interactions in autism spectrum disorders: role of epigenetic mechanisms

S Tordjman, E Somogyi, N Coulon, S Kermarrec… - Frontiers in …, 2014 - frontiersin.org
Several studies support currently the hypothesis that autism etiology is based on a polygenic
and epistatic model. However, despite advances in epidemiological, molecular and clinical …

Neuronal connectivity as a convergent target of gene× environment interactions that confer risk for Autism Spectrum Disorders

M Stamou, KM Streifel, PE Goines, PJ Lein - Neurotoxicology and teratology, 2013 - Elsevier
Evidence implicates environmental factors in the pathogenesis of Autism Spectrum
Disorders (ASD). However, the identity of specific environmental chemicals that influence …

Genetic heterogeneity in autism: From single gene to a pathway perspective

JY An, C Claudianos - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
The extreme genetic heterogeneity of autism spectrum disorder (ASD) represents a major
challenge. Recent advances in genetic screening and systems biology approaches have …

Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition

W Mandy, MC Lai - Journal of Child Psychology and Psychiatry, 2016 - Wiley Online Library
Background Although autism spectrum condition (ASC) is strongly genetic in origin,
accumulating evidence points to the critical roles of various environmental influences on its …

Epigenetics at the interface of genetics and environmental factors in autism

JM LaSalle, RO Vallero, MM Mitchell - Environmental Epigenomics in …, 2013 - Springer
Autism spectrum disorders have a complex etiology, suggesting that multiple genetic and
environmental factors play a role in their etiology. The apparent rise in the prevalence of …