Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We
report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most …

Background Compared to healthy controls, severe COVID19 patients display increased
levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 …

Novel coronaviruses (nCoVs) encode ion-channel proteins called viroporins such as protein
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

Viral infection-induced activation of inflammasome complexes has both positive and
negative effects on the host. Proper activation of inflammasome complexes induces down …

Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of
proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …

Macrophages promote an early host response to infection by releasing pro-inflammatory
cytokines such as interleukin-1β (IL-1β), TNF, and IL-6. The bioactivity of IL-1β is classically …

Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …