Multi-Algorithm Analysis Reveals Pyroptosis-Linked Genes as Pancreatic Cancer Biomarkers

K Wang, S Han, L Liu, L Zhao, I Herr - Cancers, 2024 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at
advanced stages, resulting in limited treatment options and poor survival rates. To address …

Values of a novel pyroptosis-related genetic signature in predicting outcome and immune status of pancreatic ductal adenocarcinoma

X Xu, JH Liang, JH Li, QC Xu, XY Yin - Gastroenterology Report, 2022 - academic.oup.com
Background Pyroptosis is an emerging form of programmed cell death associated with
progression in malignancies. Yet, there are few studies reporting on the association …

Exploring the potential of pyroptosis-related genes in predicting prognosis and immunological characteristics of pancreatic cancer from the perspective of genome and …

J Zhang, X You, D Kang, G Zhou - Frontiers in Oncology, 2022 - frontiersin.org
Objective To probe into the role of pyroptosis-related genes in pancreatic carcinoma.
Methods Herein, we conducted a comprehensive bioinformatics analysis to evaluate tumor …

System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma

C Yan, Y Niu, F Li, W Zhao, L Ma - Journal of translational medicine, 2022 - Springer
Background Pancreatic adenocarcinoma (PAAD) is one of the most common malignant
tumors of the digestive tract. Pyroptosis is a newly discovered programmed cell death that …

Pyroptosis-related gene signature: A predictor for overall survival, immunotherapy response, and chemosensitivity in patients with pancreatic adenocarcinoma

J Zhou, J Fan, B Li, J Sun, J Wang - Heliyon, 2023 - cell.com
Background Pancreatic adenocarcinoma (PAAD) is a lethal malignancy with high levels of
heterogeneity. Pyroptosis is thought to influence the development of various tumors …

[HTML][HTML] Construction of a pyroptosis-related genes signature to improve the prognostic prediction and therapeutic drugs selection in patients with pancreatic cancer

C Li, M Wang, J Wei, W Zhang, H Liu… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Background Effective prognostic assessment and appropriate drug selection are important
for the clinical management of pancreatic cancer (PaC). Here, we aimed to establish a …

A novel refined pyroptosis and inflammasome-related genes signature for predicting prognosis and immune microenvironment in pancreatic ductal adenocarcinoma

J Zuo, C Yi, Z Chen, B Zhou, T Yang, J Lin - Scientific reports, 2022 - nature.com
Pyroptosis is an inflammatory form of cell death, which plays a key role in the development
of auto-inflammation and cancer. This study aimed to construct a pyroptosis and …

Construction and comprehensive analysis of a novel prognostic signature associated with pyroptosis molecular subtypes in patients with pancreatic adenocarcinoma

Q Huang, X Peng, Q Li, J Zhu, J Xue… - Frontiers in …, 2023 - frontiersin.org
Background Treatment of cancer with pyroptosis is an emerging strategy. Molecular
subtypes based on pyroptosis-related genes (PRGs) seem to be considered more …

A pyroptosis-related gene signature for prognosis and immune microenvironment of pancreatic cancer

S Tao, L Tian, X Wang, Y Shou - Frontiers in Genetics, 2022 - frontiersin.org
Pancreatic cancer is one of the most lethal tumors owing to its unspecific symptoms during
the early stage and multiple treatment resistances. Pyroptosis, a newly discovered …

Development of a Prognostic Model Based on Pyroptosis‐Related Genes in Pancreatic Adenocarcinoma

K Su, Y Peng, H Yu - Disease Markers, 2022 - Wiley Online Library
Background. The importance of pyroptosis in tumorigenesis and cancer progression is
becoming increasingly apparent. However, the efficacy of using pyroptosis‐related genes …