Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs;
however, its molecular mechanisms are poorly understood. Here, we use multi-omic …

Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

The study of parental lifespan has emerged as an innovative tool to advance aging biology
and our understanding of the genetic architecture of human longevity and aging‐associated …

Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

Length and quality of life are important to us all, yet identification of promising drug targets
for human aging using genetics has had limited success. In the present study, we combine …

The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …

Individuals, organs, tissues, and cells age in diverse ways throughout the lifespan.
Epigenetic clocks attempt to quantify differential aging between individuals, but they typically …

Studying the genome of centenarians may give insights into the molecular mechanisms
underlying extreme human longevity and the escape of age-related diseases. Here, we set …

'Epigenetic age acceleration'is a valuable biomarker of ageing, predictive of morbidity and
mortality, but for which the underlying biological mechanisms are not well established. Two …