Cannabinoids act via cell surface G protein-coupled receptors (CB1 and CB2) and the ion
channel receptor TRPV1. Evidence has now emerged suggesting that an additional target is …

Cannabinoids act at two classical cannabinoid receptors (CB1 and CB2), a 7TM orphan
receptor and the transmitter‐gated channel transient receptor potential vanilloid type‐1 …

Cannabinoids have been shown to possess anti-inflammatory and neuroprotective
properties, which were proposed to occur mainly via activation of the G-protein-coupled …

Cannabinoids have been used medicinally and recreationally for thousands of years and
their effects were proposed to occur mainly via activation of the G‐protein‐coupled receptor …

Since the early 2000s, evidence has been accumulating that most cannabinoid compounds
interact with the nuclear hormone family peroxisome proliferator-activated receptors …

Peroxisome proliferator-activated receptors (PPARs) have long been known as mediators of
several physiological functions, among which the best characterized are lipid metabolism …

Some cannabinoids activate the different isoforms of PPARs (α, β and γ), as shown through
the use of reporter gene assays, binding studies, selective antagonists and knockout …

Since the discovery of the cannabinoid receptors and their endogenous ligands, significant
advances have been made in studying the physiological function of the endocannabinoid …

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …

Cannabinoids can influence the immune network. Data on the impact of exogenous
cannabinoid ligands on immune function serve not only to understand how the …