Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
most prevalent neurodegenerative disease worldwide. The primary pathological hallmarks …

A key pathological feature of neurodegenerative diseases (NDs) such as Alzheimer's
disease (AD) and Parkinson's disease (PD) is the accumulation of aggregated and …

Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Two decades ago, the recognition of protein misfolding and aggregate accumulation as
defining features of neurodegenerative disease set the stage for a thorough examination of …

The autophagy–lysosomal pathway (ALP) is involved in the degradation of long-lived
proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein …

The autophagy‐lysosomal pathway (ALP) is involved in the degradation of protein
aggregates and damaged organelles. Transcription factor EB (TFEB), a major regulator of …

Multiple studies suggest that autophagy is strongly dysregulated in Alzheimer's disease (AD)
and amyotrophic lateral sclerosis (ALS), as evidenced by accumulation of numerous …

To investigate whether transcriptional factor EB (TFEB) participates in amyloid-β1–42 (Aβ1–
42)-induced pathogenesis of Alzheimer's disease (AD) and its underlying mechanisms …

Accumulating evidence implicates impairment of the autophagy‐lysosome pathway in
Alzheimer's disease (AD). Recently discovered, transcription factor EB (TFEB) is a molecule …

Macroautophagy is a catabolic process deputed to the turnover of intracellular components.
Recent studies have revealed that transcriptional regulation is a major mechanism …