Interleukin-10-alveolar macrophage cell membrane-coated nanoparticles alleviate airway inflammation and regulate Th17/regulatory T cell balance in a mouse model

JD Li, J Yin - Frontiers in Immunology, 2023 - frontiersin.org
Background Allergic airway disease (AAD) is a chronic disease characterized by airway
inflammation, bronchoconstriction, and hyperresponsiveness. Although exogenous …

Effects of nano particles on antigen-related airway inflammation in mice

K Inoue, H Takano, R Yanagisawa, M Sakurai… - Respiratory …, 2005 - Springer
Background Particulate matter (PM) can exacerbate allergic airway diseases. Although
health effects of PM with a diameter of less than 100 nm have been focused, few studies …

Synthetic nanoparticles that promote tumor necrosis factor receptor 2 expressing regulatory T cells in the lung and resistance to allergic airways inflammation

R Mohamud, JS LeMasurier, JC Boer… - Frontiers in …, 2017 - frontiersin.org
Synthetic glycine coated 50 nm polystyrene nanoparticles (NP)(PS50G), unlike ambient NP,
do not promote pulmonary inflammation, but instead, render lungs resistant to the …

Anti-ST2 Nanoparticle Alleviates Lung Inflammation by Targeting ILC2s-CD4+T Response

Y Wu, W Shi, H Wang, J Yue, Y Mao… - International Journal …, 2020 - Taylor & Francis
Background Asthma has been regarded as an inflammatory disease, and group 2 innate
lymphoid cells (ILC2s) are implicated in asthma pathogenesis. However, no strategy is …

Aggravating impact of nanoparticles on immune‐mediated pulmonary inflammation

KI Inoue, H Takano - The Scientific World Journal, 2011 - Wiley Online Library
Although the adverse health effects of nanoparticles have been proposed and are being
clarified, their aggravating effects on pre‐existing pathological conditions have not been fully …

Lipopolysaccharide-activated bone marrow-derived dendritic cells suppress allergic airway inflammation by ameliorating the immune microenvironment

Z Min, Y Zeng, T Zhu, B Cui, R Mao, M Jin… - Frontiers in …, 2021 - frontiersin.org
Background Previous studies have shown that lipopolysaccharide (LPS)-activated bone
marrow-derived dendritic cells (DClps) might induce tolerance in autoimmune and cancer …

Differential therapeutic activity of a cargo-free nanoparticle in eosinophilic and neutrophilic asthma mouse models

X Liu, H Zhang, H Ma, J Gong, K Huang, L Wang… - Chemical Engineering …, 2023 - Elsevier
Asthma is a complex, heterogeneous chronic airway inflammatory disorder, which can be
simply categorized into eosinophilic and neutrophilic asthma. Although most patients with …

A novel anti-IL4Rα nanoparticle efficiently controls lung inflammation during asthma

R Halwani, A Sultana Shaik, E Ratemi, S Afzal… - … & Molecular Medicine, 2016 - nature.com
Drug resistance and the harmful side effects accompanying the prolonged corticosteroid
treatment of chronic pulmonary diseases prompted the development of more specific anti …

Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation

BL Scotland, S Dharmaraj, AL Cottingham… - Drug Delivery and …, 2024 - Springer
Allergic disease is a major global health concern that imposes significant life-altering and
economic burdens on affected individuals. However, there is still no cure. Polymer-based …

Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre-and postsensitization

CB Smarr, WT Yap, TP Neef… - Proceedings of the …, 2016 - National Acad Sciences
Specific immunotherapy (SIT) is the most widely used treatment for allergic diseases that
directly targets the T helper 2 (Th2) bias underlying allergy. However, the most widespread …