The sensing of self RNA by the endosomal Toll-like receptors (TLRs) 7 and 8 initiates
pathogenic mechanisms underlying the autoimmune disease lupus. A blockade of the …

Toll-like receptor (TLR) 7 and TLR8 are transmembrane receptors that recognize single-
stranded RNA. Activation of these receptors results in immune cell stimulation and …

Genetic and in vivo evidence suggests that aberrant recognition of RNA-containing
autoantigens by Toll-like receptors (TLRs) 7 and 8 drives autoimmune diseases. Here we …

Toll‐like receptors (TLRs) are innate immune receptors that respond to both exogenous and
endogenous stimuli and are suggested to contribute to the perpetuation of chronic …

The first‐in‐human phase I study for E6742, a dual toll‐like receptor (TLR) 7 and TLR8
antagonist, has been conducted to assess the safety, tolerability, and pharmacokinetics of …

Toll-like receptor 7 (TLR7) and TLR8 are single-stranded RNA-sensing endosomal pattern
recognition receptors that evolved to defend against viral infections. However, aberrant …

Antibodies (Abs) to RNA-and DNA-containing autoantigens are characteristic of systemic
lupus erythematosus (SLE). We showed previously that Toll-like receptor (TLR) 9 …

Several studies have implicated Toll-like receptors (TLRs) 7, 8 and 9 in the development
and progression of lupus. We have developed IMO-8400, a synthetic DNA-based antagonist …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the
loss of tolerance to self-nuclear antigens. Accumulating evidence shows that Toll-like …

Abstract Toll-like receptor 7 (TLR7) recognizes both microbial and endogenous RNAs and
nucleosides. Aberrant activation of TLR7 has been implicated in several autoimmune …