The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell
types holds great promise for regenerative medicine. We reported previously that cardiac …

Cardiac fibroblasts can be reprogrammed to cardiomyocyte-like cells by the introduction of
three transcription factors: Gata4, Mef2c and Tbx5 (collectively referred to here as GMT) …

The adult mammalian heart possesses little regenerative potential following injury. Fibrosis
due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss …

Heart disease remains a leading cause of death worldwide. Owing to the limited
regenerative capacity of heart tissue, cardiac regenerative therapy has emerged as an …

The mammalian heart has a very limited regenerative capacity and, hence, heals by scar
formation. Recent reports suggest that haematopoietic stem cells can transdifferentiate into …

The reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) raises the
possibility that a somatic cell could be reprogrammed to an alternative differentiated fate …

A significant bottleneck in cardiovascular regenerative medicine is the identification of a
viable source of stem/progenitor cells that could contribute new muscle after ischaemic heart …

Rationale: Direct reprogramming of fibroblasts into cardiomyocytes is a novel strategy for
cardiac regeneration. However, the key determinants involved in this process are unknown …

Dear Editor, Loss or dysfunction of cardiomyocytes lead to heart failure which is a leading
cause of death worldwide. 1 It is widely known that the hearts of adult mammals have a very …

The use of stem cells to generate replacement cells for damaged heart muscle, valves,
vessels and conduction cells holds great potential. Recent identification of multipotent …