Exploiting clinical trial data drastically narrows the window of possible solutions to the problem of clinical adaptation of a multiscale cancer model
The development of computational models for simulating tumor growth and response to
treatment has gained significant momentum during the last few decades. At the dawn of the …
treatment has gained significant momentum during the last few decades. At the dawn of the …
Towards in silico oncology: adapting a four dimensional nephroblastoma treatment model to a clinical trial case based on multi-method sensitivity analysis
In the past decades a great progress in cancer research has been made although medical
treatment is still widely based on empirically established protocols which have many …
treatment is still widely based on empirically established protocols which have many …
Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm
The challenge of modelling cancer presents a major opportunity to improve our ability to
reduce mortality from malignant neoplasms, improve treatments and meet the demands …
reduce mortality from malignant neoplasms, improve treatments and meet the demands …
The technologically integrated oncosimulator: combining multiscale cancer modeling with information technology in the in silico oncology context
This paper outlines the major components and function of the technologically integrated
oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer …
oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer …
The" Oncosimulator": a multilevel, clinically oriented simulation system of tumor growth and organism response to therapeutic schemes. Towards the clinical …
The" Oncosimulator" is at the same time a concept of multilevel integrative cancer and
(treatment affected) normal tissue biology, an algorithmic construct and a software tool which …
(treatment affected) normal tissue biology, an algorithmic construct and a software tool which …
'In silico'oncology for clinical decision making in the context of nephroblastoma
The present paper outlines the initial version of the ACGT (Advancing Clinico-Genomic
Trials)–an Integrated Project, partly funded by the EC (FP6-2005-IST-026996) I …
Trials)–an Integrated Project, partly funded by the EC (FP6-2005-IST-026996) I …
Mathematical modeling of tumor growth and treatment
H Enderling, M AJ Chaplain - Current pharmaceutical design, 2014 - ingentaconnect.com
Using mathematical models to simulate dynamic biological processes has a long history.
Over the past couple of decades or so, quantitative approaches have also made their way …
Over the past couple of decades or so, quantitative approaches have also made their way …
Models of models: a translational route for cancer treatment and drug development
LA Ogilvie, A Kovachev, C Wierling, BMH Lange… - Frontiers in …, 2017 - frontiersin.org
Every patient and every disease is different. Each patient therefore requires a personalized
treatment approach. For technical reasons, a personalized approach is feasible for treatment …
treatment approach. For technical reasons, a personalized approach is feasible for treatment …
In silico oncology: exploiting clinical studies to clinically adapt and validate multiscale oncosimulators
GS Stamatakos, E Kolokotroni… - 2013 35th Annual …, 2013 - ieeexplore.ieee.org
This paper presents a brief outline of the notion and the system of oncosimulator in
conjunction with a high level description of the basics of its core multiscale model simulating …
conjunction with a high level description of the basics of its core multiscale model simulating …
A multiscale cell‐based model of tumor growth for chemotherapy assessment and tumor‐targeted therapy through a 3D computational approach
Objectives Computational modeling of biological systems is a powerful tool to clarify diverse
processes contributing to cancer. The aim is to clarify the complex biochemical and …
processes contributing to cancer. The aim is to clarify the complex biochemical and …