Mammalian cells express a variety of innate immune proteins—known as restriction factors—
which defend against invading retroviruses such as HIV-1. Two members of the tripartite …

The recent identification of antiretroviral tripartite motif-bearing restriction factors that protect
against retroviral infection has revealed a novel branch of innate immunity. The factors target …

The host protein TRIM5α inhibits retroviral infection at an early post-penetration stage by
targeting the incoming viral capsid. While the detailed mechanism of restriction remains …

The host restriction factor TRIM5α mediates species-specific, early blocks to retrovirus
infection; susceptibility to these blocks is determined by viral capsid sequences. Here we …

TRIM5 is a restriction factor that blocks retrovirus infection soon after the virion core enters
the cell cytoplasm. Restriction activity is targeted to the virion core via recognition of the …

TRIM5α proteins are restriction factors that protect mammalian cells from retroviral infections
by binding incoming viral capsids, accelerating their dissociation, and preventing reverse …

TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids
and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains …

Rhesus TRIM5α (TRIM5αrh) is a cytosolic protein that potently restricts HIV-1 at an early
postentry stage, prior to reverse transcription. The ability of TRIM5αrh to block HIV-1 …

The retroviral restriction factor, TRIM5α, blocks infection of a spectrum of retroviruses soon
after virus entry into the cell. TRIM5α consists of RING, B-box 2, coiled-coil, and B30. 2 …

An intact B-box 2 domain is essential for the antiretroviral activity of TRIM5α. We modeled
the structure of the B-box 2 domain of TRIM5α based on the existing three-dimensional …