Genomics has made enormous progress in the twelve years since the publication of the first
draft human genome sequence, but it has not yet been translated into the clinic. Despite …

Modeling and informatics in drug design Page 19 1 1 MODELING AND INFORMATICS IN DRUG
DESIGN Prasad V. Bharatam,* Smriti Khanna, and Sandrea M. Francis National Institute of …

The enormous pressure that the pharmaceutical and biotech companies are facing, has
created the need to apply all available techniques to decrease attrition rates, costs and the …

Despite the promises made that genomic sequencing would transform therapy by
introducing a new era of personalized medicine, relatively few tangible breakthroughs have …

Computational models of cells, tissues and organisms are necessary for increased
understanding of biological systems. In particular, modeling approaches will be crucial for …

The drug discovery and development process has become more quantitative and much
more computationally intensive in recent years. For pharmaceutical and biotechnology …

Combinations of therapies are being actively pursued to expand therapeutic options and
deal with cancer's pervasive resistance to treatment. Research efforts to discover effective …

Cancer is a highly heterogeneous disease with complex underlying biology. For these
reasons, effective cancer treatment is still a challenge. Nowadays, it is clear that a cancer …

Highlights•We introduce models at molecular, cellular and omics, and organ and system
levels.•Models share mathematics as the language and informatics as a tool to study …

Inferring potential drug indications, for either novel or approved drugs, is a key step in drug
development. Previous computational methods in this domain have focused on either drug …