The challenge of HIV-1 subtype diversity

BS Taylor, ME Sobieszczyk… - … England Journal of …, 2008 - Mass Medical Soc
HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as
classifiable into distinct subtypes needs to reflect the reality of the constant emergence of …

Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy

PJ Easterbrook, M Smith, J Mullen, S O'Shea… - Journal of the …, 2010 - Springer
Background Our intention was to compare the rate of immunological progression prior to
antiretroviral therapy (ART) and the virological response to ART in patients infected with …

Is HIV-1 evolving to a less virulent form in humans?

KK Ariën, G Vanham, EJ Arts - Nature Reviews Microbiology, 2007 - nature.com
During the rapid spread of HIV-1 in humans, the main (M) group of HIV-1 has evolved into
ten distinct subtypes, undergone countless recombination events and diversified …

HIV-1 subtypes: epidemiology and significance for HIV management

AM Geretti - Current opinion in infectious diseases, 2006 - journals.lww.com
Genetic differences among HIV-1 variants can influence the virus biological properties,
susceptibility to existing and candidate antiretroviral drugs, and evolution of antiretroviral …

Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance

S Spira, MA Wainberg, H Loemba… - Journal of …, 2003 - academic.oup.com
HIV-1 infection is characterized by genetic diversity wherein distinct viral subtypes (clades A,
B, C, D, E, F, G, K and O) are expanding in different geographical regions. This article deals …

Implications of HIV diversity for the HIV-1 pandemic

J Hemelaar - Journal of Infection, 2013 - Elsevier
HIV-1 genetic variability within individuals and populations plays a central role in the HIV
pandemic. Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV …

Human immunodeficiency virus type 1 subtype distribution in the worldwide epidemic: pathogenetic and therapeutic implications

L Buonaguro, ML Tornesello, FM Buonaguro - Journal of virology, 2007 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) is the causative agent of AIDS (10, 38, 105,
114). It is characterized by extensive and dynamic genetic diversity, generating variants …

Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology

F Gao, L Yue, DL Robertson, SC Hill, H Hui… - Journal of …, 1994 - Am Soc Microbiol
The virulence properties of human immunodeficiency virus type 2 (HIV-2) are known to vary
significantly and to range from relative attenuation in certain individuals to high-level …

The public health significance of HIV-1 subtypes

ID Tatt, KL Barlow, A Nicoll, JP Clewley - Aids, 2001 - journals.lww.com
Since the first descriptions of HIV/AIDS, HIV-1 has emerged as the most significant pathogen
worldwide, with approaching 60 million infections to the end of 2000. Over 18 million deaths …

HIV-1 genetic diversity

FE McCutchan, MO Salminen, JK Carr, DS Burke - Aids, 1996 - journals.lww.com
Background: HIV-1 evolves by rapid mutation and by recombination, both processes actively
contributing to its genetic diversity. Most of the multiple genetic subtypes and intersubtype …