The clinical translation of stem cells and their extracellular vesicles (EVs)-based therapy for
central nervous system (CNS) diseases is booming. Nevertheless, the insufficient CNS …

Neurological disorders are diseases of the central nervous system (CNS), characterized by
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …

Stem cells, upon entering the CNS, can preferentially migrate into disease foci, where they
exert therapeutic effects that compensate for lost tissue, reconstructing damaged neuronal …

Introduction: Stem cell-based therapy has proved to be a promising treatment option for
neurological disorders. However, there are difficulties in successfully administrating these …

Extracellular vesicles (EVs), natural nano-vesicles carrying multiple bioactive molecules,
have been broadly applied in brain diseases due to their excellent biocompatibility, low …

Stem cells are characterized by their self-renewal and multipotency and have great potential
in the therapy of various disorders. However, the blood–brain barrier (BBB) limits the …

Exosomes, lipid bilayer-enclosed small cellular vesicles, are actively secreted by various
cells and play crucial roles in intercellular communication. These nanosized vesicles …

Neurodegenerative diseases are fatal disorders of the central nervous system (CNS) which
currently lack effective treatments. The application of mesenchymal stem cells (MSCs) …

Neurological disorders are a leading cause of morbidity worldwide, giving rise to a growing
need to develop treatments to revert their symptoms. This review highlights the great …

Intranasal administration is a promising strategy to enhance the delivery of the sEVsomes-
based drug delivery system to the central nervous system (CNS). This study aimed to …