Background Arterial stiffness (AS) is an independent risk factor for cardiovascular
morbidity/mortality. Smooth muscle cell (SMC) proliferation and increased collagen …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and
hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L …

OBJECTIVE: Alterations of wall shear stress can predispose the endothelium to the
development of atherosclerotic plaques. Ample evidence indicates that arginase expression …

Enhanced vascular arginase activity can impair endothelium-dependent vasorelaxation by
decreasing l-arginine availability to endothelial nitric oxide (NO) synthase, thereby reducing …

Background Cardiovascular disorders associated with endothelial dysfunction, such as
atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature …

Vascular and associated ventricular stiffness is one of the hallmarks of the aging
cardiovascular system. Both an increase in reactive oxygen species production and a …

Enhanced vascular arginase activity impairs endothelium-dependent vasorelaxation by
decreasing l-arginine availability to endothelial nitric oxide (NO) synthase, thereby reducing …

Background Cigarette smoke increases the risk of several cardiovascular diseases and has
synergistic detrimental effects when present with other risks that contribute to its …

Arginase metabolizes the semi-essential amino acid l-arginine to l-ornithine and urea. There
are two distinct isoforms of arginase, arginase I and II, which are encoded by separate …