[HTML][HTML] Metabolomics based predictive classifier for early detection of pancreatic ductal adenocarcinoma

K Unger, KY Mehta, P Kaur, Y Wang, SS Menon… - Oncotarget, 2018 - ncbi.nlm.nih.gov
The availability of robust classification algorithms for the identification of high risk individuals
with resectable disease is critical to improving early detection strategies and ultimately …

Evaluating metabolite-based biomarkers for early diagnosis of pancreatic cancer: a systematic review

G Perazzoli, OM García-Valdeavero, M Pena, J Prados… - Metabolites, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with five-year
survival rates around 10%. The only curative option remains complete surgical resection, but …

Discovery of pancreatic adenocarcinoma biomarkers by untargeted metabolomics

A Martín-Blázquez, C Jiménez-Luna, C Díaz… - Cancers, 2020 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal
cancers, with a 5-year survival rate of less than 5%. In fact, complete surgical resection …

A metabolomics-based biomarker signature discriminates pancreatic cancer from chronic pancreatitis

E Costello - Gut, 2018 - gut.bmj.com
The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing. The projection
that it will surpass breast cancer to become the second-leading cause of cancer-related …

A unique urinary metabolomic signature for the detection of pancreatic ductal adenocarcinoma

S Sahni, AR Pandya, WJ Hadden… - … Journal of Cancer, 2021 - Wiley Online Library
Our study aimed to identify a urinary metabolite panel for the detection/diagnosis of
pancreatic ductal adenocarcinoma (PDAC). PDAC continues to have poor survival …

Potential metabolite biomarkers for early detection of stage-I pancreatic ductal adenocarcinoma

Y Cao, R Zhao, K Guo, S Ren, Y Zhang, Z Lu… - Frontiers in …, 2022 - frontiersin.org
Background & Objectives Pancreatic ductal adenocarcinoma remains an extremely
malignant tumor having a poor prognosis. The 5-year survival rate of PDAC is related to its …

A plasma-derived protein-metabolite multiplexed panel for early-stage pancreatic cancer

JF Fahrmann, LE Bantis, M Capello… - JNCI: Journal of the …, 2019 - academic.oup.com
Background We applied a training and testing approach to develop and validate a plasma
metabolite panel for the detection of early-stage pancreatic ductal adenocarcinoma (PDAC) …

Biomarkers for pancreatic cancer based on tissue and serum metabolomics analysis in a multicenter study

R Zhao, S Ren, C Li, K Guo, Z Lu, L Tian, J He… - Cancer …, 2023 - Wiley Online Library
Background Early detection of pancreatic ductal adenocarcinoma (PDAC) may improve the
prognosis of patients. This study was to identify metabolic features of PDAC and to discover …

Meta-analysis reveals both the promises and the challenges of clinical metabolomics

HE Roth, R Powers - Cancers, 2022 - mdpi.com
Simple Summary A highly desirable approach to diagnose a human disease quickly and
easily is to identify a chemical, protein, or antibody in a biofluid like blood or urine that is …

[HTML][HTML] Metabolomic biomarkers of pancreatic cancer: a meta-analysis study

KY Mehta, HJ Wu, SS Menon, Y Fallah, X Zhong… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) is an aggressive disease with high mortality rates, however, there is
no blood test for early detection and diagnosis of this disease. Several research groups …