Glioblastoma multiforme (GBM) is a highly invasive primary brain tumour that has poor
prognosis despite aggressive treatment. A hallmark of these tumours is diffuse invasion into …

Glioblastoma multiforme (GBM) is a class of primary brain tumours characterized by their
ability to rapidly proliferate and diffusely infiltrate surrounding brain tissue. The aggressive …

Glioblastoma multiforme (GBM) are aggressive and uniformly fatal primary brain tumors
characterized by their diffuse invasion of the normal-appearing parenchyma peripheral to …

The microenvironment of a tumour, in particular its hypoxic status, is a crucial factor in its
response to radiotherapy. Conventional techniques for measuring hypoxia are either …

BACKGROUND AND PURPOSE: Positron emission tomography (PET) imaging with [F-18]
fluoromisonidazole (FMISO) has been validated as a hypoxic tracer [1, 2]. Head and neck …

High-grade gliomas are an aggressive and invasive malignancy which are susceptible to
treatment resistance due to heterogeneity in intratumoral properties such as cell proliferation …

A multiscale tumour simulation model employing cell-line-specific biological parameters and
functional information derived from pre-therapy PET/CT imaging data was developed to …

Glioblastoma (GBM) is a highly invasive brain tumor, whose cells infiltrate surrounding
normal brain tissue beyond the lesion outlines visible in the current medical scans. These …

Simple Summary Using medical imaging data and computational models, we develop a
modeling framework to provide personalized treatment response forecasts to fractionated …

Purpose There is growing recognition that biologic features of the tumor microenvironment
affect the response to cancer therapies and the outcome of cancer patients. In head and …