Sphingolipids are structurally and functionally diverse molecules with significant physiologic
functions and are found associated with cellular membranes and plasma lipoproteins. The …

Metabolic disease, including obesity and type 2 diabetes, constitutes a major emerging
health crisis in Western nations. Although the symptoms and clinical pathology and …

Sphingolipids are a family of lipid molecules produced through different pathways in
mammals. Sphingolipids are structural components of membranes, but in response to …

Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical
cellular functions. The past two decades have seen significant advances in sphingolipid …

The contribution of aberrant production of bioactive lipids to pathophysiological changes
associated with obesity has risen to the forefront of lipid research. Increased diacylglycerol …

Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and
cardiovascular disease. Sphingolipids such as ceramide and glucosylceramides, while …

Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …

Despite considerable attention to the question of how sphingolipids induce metabolic
disease, there exist enormous gaps in knowledge. Further elucidation of these molecular …

Studies of bioactive lipids in general and sphingolipids in particular have intensified over the
past several years, revealing an unprecedented and unanticipated complexity of the …

Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …