The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation
of mood, cognition and behavior and has been implicated in the pathophysiology of major …

Objective: Previous research has provided conflicting information regarding the pattern of
brain activation associated with cognitive performance in depressed people. We aimed to …

Background Patients suffering from major depressive disorder (MDD) show deficits in
working memory (WM) performance accompanied by bilateral fronto-parietal BOLD signal …

BackgroundIn patients with major depressive disorder (MDD), functional neuroimaging
studies have reported an increased activation of the dorsolateral prefrontal cortex (DLPFC) …

While cognitive impairments are well documented for the acute episode of major depressive
disorder (MDD), less is known about cognitive functioning in the euthymic state. For working …

Background Functional magnetic resonance imaging (fMRI) studies in major depressive
disorder (MDD) have revealed cortical-limbic-subcortical dysfunctions during working …

Several neuroimaging studies have reported 'hypofrontality'in depressed patients
performing a cognitive challenge compared to control subjects. Hypofrontality in depression …

Objective: The authors sought to better understand the neural circuitry associated with
working memory deficits in psychotic major depression by examining brain function during …

BACKGROUND: Executive deficits associated with frontal lobe dysfunction are prominent in
depression. We applied a newly developed WM task to investigate the neural correlates of …

The profile of cognitive dysfunction observed in patients with major depressive disorder
(MDD) may be partially attributed to a deficit in the central executive component of working …