Through alternative processing of pre-messenger RNAs, individual mammalian genes often
produce multiple mRNA and protein isoforms that may have related, distinct or even …

PAIRWISE recognition of splice sites as a result of a scanning mechanism is an attractive
model to explain the coordination of vertebrate splicing1. Such a mechanism would predict a …

Only a small proportion of the mouse genome is transcribed into mature messenger RNA
transcripts. There is an international collaborative effort to identify all full-length mRNA …

One of the most interesting opportunities in comparative genomics is to compare not only
genome sequences but additional phenomena, such as alternative splicing, using …

Most mammalian genes produce multiple distinct messenger RNAs through alternative
splicing, but the extent of splicing conservation is not clear. To assess tissue-specific …

Alternative splicing has a crucial role in the generation of biological complexity, and its
misregulation is often involved in human disease. Here we describe the assembly of a …

It is generally believed that splicing removes introns as single units from precursor
messenger RNA transcripts. However, some long Drosophila melanogaster introns contain …

The functional complexity of the human transcriptome is not yet fully elucidated. We report a
high-throughput sequence of the human transcriptome from a human embryonic kidney and …

THE recent discovery that many eukaryotic structural genes are interrupted by stretches
(sometimes very long) of non-informational'intervening'DNA, _, is the latest and most …

Regulation of transcript structure generates transcript diversity and plays an important role in
human disease,,,,,–. The advent of long-read sequencing technologies offers the opportunity …