The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Single-cell techniques are advancing rapidly and are yielding unprecedented insight into
cellular heterogeneity. Mapping the gene regulatory networks (GRNs) underlying cell states …

Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …

Gene regulatory networks (GRNs) are key determinants of cell function and identity and are
dynamically rewired during development and disease. Despite decades of advancement …

Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory
networks (GRNs) that connect transcription factors and signaling proteins to target genes …

Inferring gene regulatory networks (GRNs) based on gene expression profiles is able to
provide an insight into a number of cellular phenotypes from the genomic level and reveal …

PERSPECTIVE interplay of signal transduction, transcriptional, post-transcriptional,
metabolic and other regulatory events that determine cell behavior. Even today, entirely new …

Cells require coordinated control over gene expression when responding to environmental
stimuli. Here we apply scATAC-seq and single-cell RNA sequencing (scRNA-seq) in resting …

With the advent of recent next-generation sequencing (NGS) technologies in genomics,
transcriptomics, and epigenomics, profiling single-cell sequencing became possible. The …