Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions

B Doshi, SR Athans, A Woloszynska - Oncogenesis, 2023 - nature.com
Sex and gender disparities in bladder cancer have long been a subject of interest to the
cancer research community, wherein men have a 4 times higher incidence rate than women …

Sex differences in bladder cancer: emerging data and call to action

D Theodorescu, Z Li, X Li - Nature Reviews Urology, 2022 - nature.com
Incidence and mortality disparities between males and females exist in many diseases
including bladder cancer, but the mechanisms remain unclear. To adequately address this …

The impact of gender on oncologic outcomes of bladder cancer

DH Mun, S Kimura, SF Shariat… - Current Opinion in …, 2019 - journals.lww.com
A steadily growing body of evidence reveals that women present with more advanced BCa
and have stage-for-stage worse outcome compared with men. The underlying mechanisms …

The sex gap in bladder cancer survival—a missing link in bladder cancer care?

P Toren, A Wilkins, K Patel, A Burley, T Gris… - Nature Reviews …, 2024 - nature.com
The differences in bladder cancer outcomes between the sexes has again been highlighted.
Uncommon among cancers, bladder cancer outcomes are notably worse for women than for …

Sex differences in bladder cancer immunobiology and outcomes: a collaborative review with implications for treatment

M Koti, MA Ingersoll, S Gupta, CM Lam, X Li… - European Urology …, 2020 - Elsevier
Context Urothelial carcinoma of the bladder (UCB) exhibits significant sexual dimorphism in
the incidence, etiology, and response to intravesical immunotherapy. Environmental factors …

[HTML][HTML] The impact of biological sex on diseases of the urinary tract

L Deltourbe, LL Mariano, TN Hreha, DA Hunstad… - Mucosal …, 2022 - Elsevier
Biological sex, being female or male, broadly influences diverse immune phenotypes,
including immune responses to diseases at mucosal surfaces. Sex hormones, sex …

Gender and bladder cancer: a collaborative review of etiology, biology, and outcomes

J Dobruch, S Daneshmand, M Fisch, Y Lotan, AP Noon… - European urology, 2016 - Elsevier
Context The incidence of bladder cancer is three to four times greater in men than in women.
However, women are diagnosed with more advanced disease at presentation and have less …

Spotlight on gender-specific disparities in bladder cancer

M Mancini, M Righetto, G Baggio - Urologia Journal, 2020 - journals.sagepub.com
Men are at a higher risk of developing bladder cancer, but women present with more
advanced disease and have more unfavourable outcomes. Although epidemiologic and …

Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance

HA Abdel-Hafiz, SKK Mani, W Huang, KH Gouin… - Iscience, 2023 - cell.com
Bladder cancer (BLCA) is more common in men but more aggressive in women. Sex-based
differences in cancer biology are commonly studied using a murine model with BLCA …

[HTML][HTML] Sexual dimorphism in outcomes of non–muscle-invasive bladder cancer: a role of CD163+ macrophages, B cells, and PD-L1 immune checkpoint

S Chenard, C Jackson, T Vidotto, L Chen… - European Urology Open …, 2021 - Elsevier
Background Non–muscle-invasive bladder cancer (NMIBC) is over three times as common
in men as it is in women; however, female patients do not respond as well to …