Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

As the current paradigms of drug discovery evolve, it has become clear that a more
comprehensive understanding of the interactions between small molecules and organismal …

The zebrafish model organism is increasingly used for assessing drug toxicity and safety
and numerous studies confirm that mammalian and zebrafish toxicity profiles are strikingly …

Over the past decade, zebrafish are being increasingly used in assessing the effects of
chemical compounds. Especially, the embryos and larvae, due to their microscopically small …

Introduction: Over the past decade, zebrafish have been tasked to play important roles from
modeling human diseases to finding cures for them. Inadvertently, these fish now find …

Zebrafish are vertebrate organisms that are of growing interest for preclinical drug discovery
applications. Zebrafish embryos develop most of the major organ systems present in …

Introduction: Off-target effects represent one of the major concerns in the development of
new pharmaceuticals, requiring large-scale animal toxicity testing. Faster, cheaper and more …

The traditional drug discovery pipeline for the identification and development of compounds
that selectively target specific molecules to ameliorate disease remains a major focus for …

Anecdotal evidence has long suggested that zebrafish may be a good model to predict
toxicity of human drugs. As summarized in this review, several groups have recently …

Toxicity, due to complications of in vivo adsorption, distribution, metabolism and excretion
(ADME), is a major cause of failure during drug development; many drugs shown to be safe …