Following the discovery of HIV as a causative agent of AIDS, the expectation was to rapidly
develop a vaccine; but thirty years later, we still do not have a licensed vaccine. Progress …

Of any pathogen, HIV provides perhaps the greatest challenge to successful vaccine
development. Nevertheless, progress continued to be made in 2018; new vaccine concepts …

Despite more than 25 years of concerted worldwide research, the development of a safe and
effective HIV-1 vaccine remains elusive. Prototype antibody-based and T cell–based HIV-1 …

An efficacious HIV-1 vaccine is regarded as the best way to halt the ongoing HIV-1
epidemic. However, despite significant efforts to develop a safe and effective vaccine, the …

Introduction The development of an effective vaccine to protect against HIV is a longstanding
global health need complicated by challenges inherent to HIV biology and to the execution …

HIV is a virus that remains a major health concern and results in an infection that has no
cure even after over 30 years since its discovery. As such, HIV vaccine discovery continues …

Many attempts have been made or are ongoing for HIV prevention and HIV cure. Many
successes are in the list, particularly for HIV drugs, recently proposed also for prevention …

The past 2 years have seen a number of basic and translational science advances in the
quest for development of an effective HIV-1 vaccine. These advances include discovery of …

The development of a safe, effective and globally affordable HIV vaccine offers the best
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …

HIV-1 and its simian counterpart SIV have been exquisitely tailored by evolution to evade
host immunity. By virtue of specific adaptations that thwart individual innate or adaptive …