Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing

M Zhang, S Hu, M Min, Y Ni, Z Lu, X Sun, J Wu, B Liu… - Gut, 2021 - gut.bmj.com
Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and
treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas …

Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing

SS Wong, KM Kim, JC Ting, K Yu, J Fu, S Liu… - Nature …, 2014 - nature.com
Gastric cancer (GC) is the second most common cause of cancer-related deaths. It is known
to be a heterogeneous disease with several molecular and histological subtypes. Here we …

Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer

KK Huang, J Huang, JKL Wu, M Lee, ST Tay, V Kumar… - Genome biology, 2021 - Springer
Background Deregulated gene expression is a hallmark of cancer; however, most studies to
date have analyzed short-read RNA sequencing data with inherent limitations. Here, we …

Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy

K Chen, D Yang, X Li, B Sun, F Song… - Proceedings of the …, 2015 - National Acad Sciences
Gastric cancer (GC) is a highly heterogeneous disease. To identify potential clinically
actionable therapeutic targets that may inform individualized treatment strategies, we …

Identification of a molecular signature of prognostic subtypes in diffuse-type gastric cancer

SK Kim, HJ Kim, JL Park, H Heo, SY Kim, SI Lee… - Gastric Cancer, 2020 - Springer
Background Although recent advances in high-throughput technology have provided many
insights into gastric cancer (GC), few reliable biomarkers for diffuse-type GC have been …

Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity

J Kim, C Park, KH Kim, EH Kim, H Kim, JK Woo… - NPJ precision …, 2022 - nature.com
Single-cell transcriptomic profiles analysis has proposed new insights for understanding the
behavior of human gastric cancer (GC). GC offers a unique model of intratumoral …

Dissection of gastric cancer heterogeneity for precision oncology

SWT Ho, P Tan - Cancer science, 2019 - Wiley Online Library
Gastric cancer (GC) remains the fifth most prevalent cancer worldwide and the third leading
cause of global cancer mortality. Comprehensive‐omic studies have unveiled a …

Revealing the transcriptional heterogeneity of organ‐specific metastasis in human gastric cancer using single‐cell RNA sequencing

H Jiang, D Yu, P Yang, R Guo, M Kong… - Clinical and …, 2022 - Wiley Online Library
Background Deciphering intra‐and inter‐tumoural heterogeneity is essential for
understanding the biology of gastric cancer (GC) and its metastasis and identifying effective …

[HTML][HTML] Dissecting the single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancer

P Zhang, M Yang, Y Zhang, S Xiao, X Lai, A Tan, S Du… - Cell reports, 2019 - cell.com
Intestinal-type gastric cancer is preceded by premalignant lesions, including chronic
atrophic gastritis and intestinal metaplasia. In this study, we constructed a single-cell atlas …

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

R Cristescu, J Lee, M Nebozhyn, KM Kim, JC Ting… - Nature medicine, 2015 - nature.com
Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We
aim to establish clinically relevant molecular subtypes that would encompass this …