Mitochondrial dysfunction: the hidden player in the pathogenesis of atherosclerosis?

G Ciccarelli, S Conte, G Cimmino, P Maiorano… - International Journal of …, 2023 - mdpi.com
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes.
Improvements in therapy have drastically reduced the prognosis of cardiovascular disease …

Mitochondrial dysfunction and DNA damage in the context of pathogenesis of atherosclerosis

T Shemiakova, E Ivanova, AV Grechko, EV Gerasimova… - Biomedicines, 2020 - mdpi.com
Atherosclerosis is a multifactorial disease of the cardiovascular system associated with
aging, inflammation, and oxidative stress. An important role in the development of …

Mitochondrial dysfunction in vascular wall cells and its role in atherosclerosis

D Salnikova, V Orekhova, A Grechko… - International Journal of …, 2021 - mdpi.com
Altered mitochondrial function is currently recognized as an important factor in
atherosclerosis initiation and progression. Mitochondrial dysfunction can be caused by …

[HTML][HTML] Atherosclerosis as mitochondriopathy: Repositioning the disease to help finding new therapies

T Shemiakova, E Ivanova, WK Wu… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a complex pathology that involves both metabolic dysfunction and chronic
inflammatory process. During the last decade, a considerable progress was achieved in …

Mitochondrial DNA damage and atherosclerosis

PK Emma, MR Bennett - Trends in Endocrinology & Metabolism, 2014 - cell.com
Mitochondria are often regarded as the cellular powerhouses through their ability to
generate ATP, the universal fuel for metabolic processes. However, in recent years …

Mitochondrion as a selective target for the treatment of atherosclerosis: Role of mitochondrial DNA mutations and defective mitophagy in the pathogenesis of …

AN Orekhov, AV Poznyak, IA Sobenin… - Current …, 2020 - ingentaconnect.com
Background: Atherosclerosis is a chronic inflammatory condition that affects different arteries
in the human body and often leads to severe neurological complications, such as stroke and …

Mitochondrial dysfunction in atherosclerosis

W Peng, G Cai, Y Xia, J Chen, P Wu, Z Wang… - DNA and cell …, 2019 - liebertpub.com
Mitochondria are highly dynamic organelles beyond powerhouses of a cell. These
components also play important roles in cell homeostasis by regulating cell function and …

Mitochondria in vascular disease

E Yu, J Mercer, M Bennett - Cardiovascular research, 2012 - academic.oup.com
Mitochondria are often regarded as the powerhouse of the cell by generating the ultimate
energy transfer molecule, ATP, which is required for a multitude of cellular processes …

The role of mitochondria in cardiovascular diseases

AV Poznyak, EA Ivanova, IA Sobenin, SF Yet… - Biology, 2020 - mdpi.com
The role of mitochondria in cardiovascular diseases is receiving ever growing attention. As a
central player in the regulation of cellular metabolism and a powerful controller of cellular …

The role of mitochondrial DNA damage in the development of atherosclerosis

PK Emma, MR Bennett - Free Radical Biology and Medicine, 2016 - Elsevier
Mitochondria are the cellular powerhouses, fuelling metabolic processes through their
generation of ATP. However we now recognise that these organelles also have pivotal roles …