Immunomodulatory and anti-inflammatory effects of berberine in lung tissue and its potential application in prophylaxis and treatment of COVID-19

A Majdalawieh, S Yousef, I Abu-Yousef, G Nasrallah - 2022 - qspace.qu.edu.qa
Natural products with known safety profiles are a promising source for the discovery of new
drug leads. Berberine presents an example of one such phytochemical that has been …

The role of berberine in Covid-19: potential adjunct therapy

AO Babalghith, HM Al-Kuraishy, AI Al-Gareeb… - …, 2022 - Springer
Abstract Coronavirus disease 2019 (Covid-19) is a global diastrophic disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Covid-19 leads to …

[HTML][HTML] A small molecule compound berberine as an orally active therapeutic candidate against COVID‐19 and SARS: A computational and mechanistic study

ZZ Wang, K Li, AR Maskey, W Huang… - The FASEB …, 2021 - ncbi.nlm.nih.gov
The novel coronavirus disease, COVID‐19, has grown into a global pandemic and a major
public health threat since its breakout in December 2019. To date, no specific therapeutic …

[PDF][PDF] Dose-dependent effect of berberine on SARS-CoV-2 spike protein induced inflammatory host cell response

I Gu, W Zhu - Int. J. Med. Sci. Health Res, 2021 - ijmshr.com
The novel Coronavirus disease 2019 (COVID-19) is the cause behind the current global
pandemic, capable of inducing pneumonia-like symptoms and lung failure. A key pathway …

[HTML][HTML] Research on the mechanism of berberine in the treatment of COVID-19 pneumonia pulmonary fibrosis using network pharmacology and molecular docking

J Cao, L Li, L Xiong, C Wang, Y Chen, X Zhang - Phytomedicine Plus, 2022 - Elsevier
Purpose Pulmonary fibrosis caused by COVID-19 pneumonia is a serious complication of
COVID-19 infection, there is a lack of effective treatment methods clinically. This article …

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases

XN Tew, NJX Lau, DK Chellappan… - Chemico-biological …, 2020 - Elsevier
Inflammatory responses play a remarkable role in the mechanisms of acute and chronic
respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma …

Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis

K Wang, J Yin, J Chen, J Ma, H Si, D Xia - Phytomedicine, 2024 - Elsevier
Abstract Background Traditional Chinese Medicine (TCM), renowned for its holistic
approach with a 2000-year history of utilizing natural remedies, offers unique advantages in …

Berberine and obatoclax inhibit SARS-Cov-2 replication in primary human nasal epithelial cells in vitro

FS Varghese, E van Woudenbergh, GJ Overheul… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a new human
pathogen in late 2019 and it has infected over 100 million people in less than a year. There …

Ameliorating effects of berberine on sepsis-associated lung inflammation induced by lipopolysaccharide: molecular mechanisms and preclinical evidence

X Li, Y Bai, Y Ma, Y Li - Pharmacological Reports, 2023 - Springer
As a life-threatening disorder, sepsis-associated lung injury is a dysregulated inflammatory
response to microbial infection, characterized by the infiltration of inflammatory cells into …

[HTML][HTML] The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19

P Kritis, I Karampela, S Kokoris, M Dalamaga - Metabolism open, 2020 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, while no
treatment has been proven effective. COVID-19 pathophysiology involves the activation of …