Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the
structural similarity between those and host nucleic acids, mammalian cells have been able …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

The innate immune system deploys a variety of sensors to detect signs of infection. Nucleic
acids represent a major class of pathogen signatures that can trigger robust immune …

Innate immune sensors that detect nucleic acids are attractive targets for therapeutic
intervention because of their diverse roles in many disease processes. In detecting RNA and …

During viral and bacterial infections, pathogen-derived cytosolic nucleic acids are
recognized by the intracellular RNA sensors retinoic acid-inducible gene I and melanoma …

Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

Recognition of DNA and RNA by endosomal and cytosolic sensors constitutes a central
element in the detection of microbial invaders by the innate immune system. However, the …

Nucleic acids (NAs) represent one of the most important classes of molecules recognized by
the innate immune system. However, NAs are not limited to pathogens, but are also present …

The host takes use of pattern recognition receptors (PRRs) to defend against pathogen
invasion or cellular damage. Among microorganism-associated molecular patterns detected …

Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …