The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …

In human embryos, major zygotic genome activation (ZGA) initiates at the eight-cell (8C)
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …

The first wave of transcription, called zygotic genome activation (ZGA), begins during the 2-
cell stage in mouse preimplantation development and marks a vital transition from the …

The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C …

After fertilization of the transcriptionally silent oocyte, expression from both parental
chromosomes is launched through zygotic genome activation (ZGA), occurring in the mouse …

How maternal factors in oocytes trigger zygotic genome activation (ZGA) is a long-standing
question in developmental biology. Recent studies in 2-cell-like embryonic stem cells (2C …

The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals
remains poorly understood. The 2-cell (2C)-like cells spontaneously emerging from cultures …

Zygotic genome activation (ZGA) denotes the initiation of gene expression after fertilization.
It is part of the complex oocyte-to-embryo transition (OET) in which a highly specialized cell …

Embryonic genome activation (EGA) is critical for embryonic development. However, our
understanding of the regulatory mechanisms of human EGA is still incomplete. Human …

Dear Editor, Zygotic genome activation (ZGA) following fertilization is accomplished through
a process termed the maternal-to-zygotic transition, during which the maternal RNAs and …