[HTML][HTML] DNA methylation-based estimator of telomere length

AT Lu, A Seeboth, PC Tsai, D Sun, A Quach… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Telomere length (TL) is associated with several aging-related diseases. Here, we present a
DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is …

[HTML][HTML] The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men

ES Epel, SS Merkin, R Cawthon, EH Blackburn… - Aging (Albany …, 2009 - ncbi.nlm.nih.gov
Telomere length (TL) has been proposed as a marker of mitotic cell age and as a general
index of human organismic aging. Short absolute leukocyte telomere length has been linked …

Telomere length and epigenetic clocks as markers of cellular aging: a comparative study

EE Pearce, R Alsaggaf, S Katta, C Dagnall, G Aubert… - Geroscience, 2022 - Springer
Telomere length (TL) and DNA methylation–based epigenetic clocks are markers of
biological age, but the relationship between the two is not fully understood. Here, we used …

[HTML][HTML] Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci

JL Buxton, M Suderman, JJ Pappas, N Borghol… - Scientific reports, 2014 - nature.com
In humans, leukocyte telomere length (LTL) is positively correlated with lifespan and shorter
LTL is associated with increased risk of age-related disease. In this study we tested for …

Telomere length measurement as a clinical biomarker of aging and disease

CL Fasching - Critical reviews in clinical laboratory sciences, 2018 - Taylor & Francis
Telomere length measurement is increasingly recognized as a clinical gauge for age-related
disease risk. There are several methods for studying blood telomere length (BTL) as a …

Telomeres and cardiovascular disease risk: an update 2013

PM Nilsson, H Tufvesson, M Leosdottir… - Translational research, 2013 - Elsevier
Leukocyte telomere length (LTL) has been regarded as a potential marker of biologic aging
because it usually shortens in a predictable way with age. Recently, a growing interest in …

Telomere length and cardiovascular risk factors in a middle‐aged population free of overt cardiovascular disease

S Bekaert, T De Meyer, ER Rietzschel… - Aging cell, 2007 - Wiley Online Library
Evidence assembled over the last decade shows that average telomere length (TL) acts as a
biomarker for biological aging and cardiovascular disease (CVD) in particular. Although …

Epigenetic clock and relative telomere length represent largely different aspects of aging in the Berlin Aging Study II (BASE-II)

VM Vetter, A Meyer, M Karbasiyan… - The Journals of …, 2019 - academic.oup.com
DNA methylation age (DNAm age;“epigenetic clock”) has recently been described as highly
correlated with chronological age. Several studies suggest that DNAm age reflects, at least …

Leukocyte telomere length is associated with noninvasively measured age-related disease: the Cardiovascular Health Study

JL Sanders, AL Fitzpatrick, RM Boudreau… - … Series A: Biomedical …, 2012 - academic.oup.com
Background. Most studies of leukocyte telomere length (LTL) focus on diagnosed disease in
one system. A more encompassing depiction of health is disease burden, defined here as …

Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither?

JL Sanders, AB Newman - Epidemiologic reviews, 2013 - academic.oup.com
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …