Telomere length (TL) has been proposed as a marker of mitotic cell age and as a general index of human organismic aging. Short absolute leukocyte telomere length has been linked …
EE Pearce, R Alsaggaf, S Katta, C Dagnall, G Aubert… - Geroscience, 2022 - Springer
Telomere length (TL) and DNA methylation–based epigenetic clocks are markers of biological age, but the relationship between the two is not fully understood. Here, we used …
JL Buxton, M Suderman, JJ Pappas, N Borghol… - Scientific reports, 2014 - nature.com
In humans, leukocyte telomere length (LTL) is positively correlated with lifespan and shorter LTL is associated with increased risk of age-related disease. In this study we tested for …
CL Fasching - Critical reviews in clinical laboratory sciences, 2018 - Taylor & Francis
Telomere length measurement is increasingly recognized as a clinical gauge for age-related disease risk. There are several methods for studying blood telomere length (BTL) as a …
Leukocyte telomere length (LTL) has been regarded as a potential marker of biologic aging because it usually shortens in a predictable way with age. Recently, a growing interest in …
S Bekaert, T De Meyer, ER Rietzschel… - Aging cell, 2007 - Wiley Online Library
Evidence assembled over the last decade shows that average telomere length (TL) acts as a biomarker for biological aging and cardiovascular disease (CVD) in particular. Although …
VM Vetter, A Meyer, M Karbasiyan… - The Journals of …, 2019 - academic.oup.com
DNA methylation age (DNAm age;“epigenetic clock”) has recently been described as highly correlated with chronological age. Several studies suggest that DNAm age reflects, at least …
Background. Most studies of leukocyte telomere length (LTL) focus on diagnosed disease in one system. A more encompassing depiction of health is disease burden, defined here as …
JL Sanders, AB Newman - Epidemiologic reviews, 2013 - academic.oup.com
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …