The advent of single-cell chromatin accessibility profiling has accelerated the ability to map
gene regulatory landscapes but has outpaced the development of scalable software to …

Technical advances have enabled the collection of genome and transcriptome data sets
with single-cell resolution. However, single-cell characterization of the epigenome has …

INTRODUCTION In recent years, the single-cell genomics field has made incredible
progress toward disentangling the cellular heterogeneity of human tissues. However, the …

We applied a combinatorial indexing assay, sci-ATAC-seq, to profile genome-wide
chromatin accessibility in∼ 100,000 single cells from 13 adult mouse tissues. We identify 85 …

Single-cell ATAC-seq (scATAC) yields sparse data that make conventional analysis
challenging. We developed chromVAR (http://www. github. com/GreenleafLab/chromVAR) …

Profiling chromatin accessibility at the single-cell level provides critical information about cell
type composition and cell-to-cell variation within a complex tissue. Emerging techniques for …

Joint profiling of transcriptome and chromatin accessibility within single cells allows for the
deconstruction of the complex relationship between transcriptional states and upstream …

The recent advancements in single-cell technologies, including single-cell chromatin
accessibility sequencing (scCAS), have enabled profiling the epigenetic landscapes for …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

Recent advances in single-cell technologies have enabled the characterization of
epigenomic heterogeneity at the cellular level. Computational methods for automatic cell …