Recent efforts have revealed that numerous protein-coding messenger RNAs have natural
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …

Although large numbers of long noncoding RNAs (lncRNAs) expressed in the mammalian
nervous system have been detected, their functions and mechanisms of regulation remain to …

In Alzheimer disease, increased β-secretase (BACE1) activity has been associated with
neurodegeneration and accumulation of amyloid precursor protein (APP) products. Thus …

Extracellular deposition of amyloid-β (Aβ) aggregates in the brain represents one of the
histopathological hallmarks of Alzheimer's disease (AD). Aβ peptides are generated from …

The β-Secretase (BACE1) is widely studied to be particularly involved in amyloid deposition,
a process known as the pathogenic pathway in neurodegenerative diseases. Therefore …

Alzheimer's disease (AD) is a devastating neurodegenerative disease that causes
progressive damage to neurons. Emerging evidence has demonstrated that long non …

As the main beta‐secretase of the central nervous system, BACE‐1 is a key protein in the
pathogenesis of Alzheimer's disease. Excessive expression of the protein might cause an …

The formation of Alzheimer's Aβ peptide is initiated when the amyloid precursor protein
(APP) is cleaved by the enzyme β-secretase (BACE1); inhibition of this cleavage has been …

Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well
established, fairly little is known about the molecular mechanisms affecting Aβ generation in …

Amyloid-β peptides (Aβ) are widely presumed to play a causal role in Alzheimer disease.
Release of Aβ from the amyloid precursor protein (APP) requires proteolysis by the β-site …