Etiology in psychiatry: embracing the reality of poly‐gene‐environmental causation of mental illness

R Uher, A Zwicker - World Psychiatry, 2017 - Wiley Online Library
Intriguing findings on genetic and environmental causation suggest a need to reframe the
etiology of mental disorders. Molecular genetics shows that thousands of common and rare …

Gene-environment interactions in psychiatry: recent evidence and clinical implications

RJ Musci, JL Augustinavicius, H Volk - Current psychiatry reports, 2019 - Springer
Abstract Purpose of Review We identify the recent evidence for gene-by-environment
interaction studies in relation to psychiatric disorders. We focus on the key genotypic data as …

Gene–environment interactions in common mental disorders: an update and strategy for a genome-wide search

R Uher - Social psychiatry and psychiatric epidemiology, 2014 - Springer
A decade of research has demonstrated the explanatory potential of interplay between
genetic variants and environmental factors in the development of common mental disorders …

[HTML][HTML] Gene-environment interaction in evolutionary perspective: differential susceptibility to environmental influences

J Belsky, S Hartman - World Psychiatry, 2014 - ncbi.nlm.nih.gov
By tradition, psychiatrists have been concerned with the nature, origins, sequelae and
treatment of mental disorders. When it comes to etiology and the role of genetics, psychiatric …

Gene–environment interplay in the etiology of psychosis

A Zwicker, EM Denovan-Wright, R Uher - Psychological medicine, 2018 - cambridge.org
Schizophrenia and other types of psychosis incur suffering, high health care costs and loss
of human potential, due to the combination of early onset and poor response to treatment …

Environmental risk factors for schizophrenia and bipolar disorder and their relationship to genetic risk: current knowledge and future directions

N Robinson, SE Bergen - Frontiers in genetics, 2021 - frontiersin.org
Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result
from complex interplay between genetic and environmental factors. It is well-established that …

Gene–environment interactions in psychiatry: joining forces with neuroscience

A Caspi, TE Moffitt - Nature Reviews Neuroscience, 2006 - nature.com
Gene–environment interaction research in psychiatry is new, and is a natural ally of
neuroscience. Mental disorders have known environmental causes, but there is …

Genotype–environment correlations: implications for determining the relationship between environmental exposures and psychiatric illness

SR Jaffee, TS Price - Psychiatry, 2008 - Elsevier
Psychosocial risk factors for psychiatric illness are moderately heritable. This has two
implications: first, that individuals actively shape their environments through heritable …

Measured gene-environment interactions in psychopathology: Concepts, research strategies, and implications for research, intervention, and public understanding of …

TE Moffitt, A Caspi, M Rutter - Perspectives on Psychological …, 2006 - journals.sagepub.com
There is much curiosity about interactions between genes and environmental risk factors for
psychopathology, but this interest is accompanied by uncertainty. This article aims to …

Genome‐Wide Findings in Schizophrenia and the Role of Gene–Environment Interplay

R Van Winkel, G Esquivel, G Kenis… - CNS neuroscience & …, 2010 - Wiley Online Library
The recent advent of genome‐wide mass‐marker technology has resulted in renewed
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …