A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions
NBM Rafiq, Y Nishimura, SV Plotnikov, V Thiagarajan… - Nature materials, 2019 - nature.com
The interrelationship between microtubules and the actin cytoskeleton in
mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show …
mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show …
Microtubules tune mechanosensitive cell responses
S Seetharaman, B Vianay, V Roca, AJ Farrugia… - Nature Materials, 2022 - nature.com
Mechanotransduction is a process by which cells sense the mechanical properties of their
surrounding environment and adapt accordingly to perform cellular functions such as …
surrounding environment and adapt accordingly to perform cellular functions such as …
Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions
BP Bouchet, RE Gough, YC Ammon, D van de Willige… - Elife, 2016 - elifesciences.org
The cross-talk between dynamic microtubules and integrin-based adhesions to the
extracellular matrix plays a crucial role in cell polarity and migration. Microtubules regulate …
extracellular matrix plays a crucial role in cell polarity and migration. Microtubules regulate …
Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation
Integrin-based adhesions play critical roles in cell migration. Talin activates integrins and
flexibly connects integrins to the actomyosin cytoskeleton, thereby serving as a 'molecular …
flexibly connects integrins to the actomyosin cytoskeleton, thereby serving as a 'molecular …
Actin–microtubule coordination at growing microtubule ends
To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into
complex structures. Although it is known that cytoskeletal coordination is vital for cell …
complex structures. Although it is known that cytoskeletal coordination is vital for cell …
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments
How different integrins that bind to the same type of extracellular matrix protein mediate
specific functions is unclear. We report the functional analysis of β1-and αv-class integrins …
specific functions is unclear. We report the functional analysis of β1-and αv-class integrins …
Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics
The cytoskeleton is a dynamic network of proteins, including actin, microtubules, and their
associated motor proteins, that enables essential cellular processes such as motility …
associated motor proteins, that enables essential cellular processes such as motility …
Molecular mechanisms of cellular mechanosensing
Mechanical forces direct a host of cellular and tissue processes. Although much emphasis
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …
Integrin nanoclusters can bridge thin matrix fibres to form cell–matrix adhesions
Integrin-mediated cell–matrix adhesions are key to sensing the geometry and rigidity of
extracellular environments and influence vital cellular processes. In vivo, the extracellular …
extracellular environments and influence vital cellular processes. In vivo, the extracellular …
The balance between actomyosin contractility and microtubule polymerization regulates hierarchical protrusions that govern efficient fibroblast–collagen interactions
Fibroblasts undergo a critical transformation from an initially inactive state to a
morphologically different and contractile state after several hours of being embedded within …
morphologically different and contractile state after several hours of being embedded within …