Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset

JFW Chan, Y Yao, ML Yeung, W Deng… - The Journal of …, 2015 - academic.oup.com
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe disease in
human with an overall case-fatality rate of> 35%. Effective antivirals are crucial for improving …

Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays

J Dyall, E Postnikova, H Zhou… - Journal of general …, 2014 - microbiologyresearch.org
The Middle East respiratory syndrome coronavirus (MERS-CoV) presents a novel emerging
threat to public health worldwide. Several treatments for infected individuals have been …

An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus

Y Yao, L Bao, W Deng, L Xu, F Li, Q Lv… - The Journal of …, 2014 - academic.oup.com
In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East
respiratory syndrome (MERS-CoV; previously known as human coronavirus–Erasmus …

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques

D Falzarano, E De Wit, AL Rasmussen, F Feldmann… - Nature medicine, 2013 - nature.com
Abstract The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) is of
global concern: the virus has caused severe respiratory illness, with 111 confirmed cases …

Animal models of Middle East respiratory syndrome coronavirus infection

N van Doremalen, VJ Munster - Antiviral research, 2015 - Elsevier
The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012
marked the second time that a new, highly pathogenic coronavirus has emerged in the …

3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

RF Johnson, U Bagci, L Keith, X Tang, DJ Mollura… - Virology, 2016 - Elsevier
Abstract Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in
2012 as the causative agent of a severe, lethal respiratory disease occurring across several …

Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)–specific human monoclonal antibody protects rabbits from MERS-CoV infection

KV Houser, L Gretebeck, T Ying, Y Wang… - The Journal of …, 2016 - academic.oup.com
With> 1600 documented human infections with Middle East respiratory syndrome
coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical …

Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets

N van Doremalen, D Falzarano, T Ying, E de Wit… - Antiviral research, 2017 - Elsevier
Abstract Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to
be identified and with a lack of effective clinical treatment and no preventative strategies …

Transmission of MERS-coronavirus in household contacts

C Drosten, B Meyer, MA Müller… - … England Journal of …, 2014 - Mass Medical Soc
Background Strategies to contain the Middle East respiratory syndrome coronavirus (MERS-
CoV) depend on knowledge of the rate of human-to-human transmission, including …

Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus

JFW Chan, KH Chan, RYT Kao, KKW To, BJ Zheng… - Journal of Infection, 2013 - Elsevier
Summary Objectives Middle East respiratory syndrome coronavirus (MERS-CoV) has
emerged to cause fatal infections in patients in the Middle East and traveler-associated …