The conceivable role of prolactin hormone in Parkinson disease: the same goal but with different ways

HM Al-Kuraishy, MS Jabir, AI Al-Gareeb… - Ageing Research …, 2023 - Elsevier
Parkinson disease (PD) is a progressive neurodegenerative disease (NDD) of the brain. It
has been reported that prolactin (PRL) hormone plays a differential effect in PD, may be …

Prolactin and its altered action in Alzheimer's disease and Parkinson's disease

H Duc Nguyen, B Pal Yu, NHM Hoang, WH Jo… - …, 2022 - karger.com
Background: Prolactin (PRL) is one of the most diverse pituitary hormones and is known to
modulate normal neuronal function and neurodegenerative conditions. Many studies have …

Decoding signaling pathways involved in prolactin-induced neuroprotection: A review

G Molina-Salinas, NA Rivero-Segura… - Frontiers in …, 2021 - Elsevier
It has been well recognized that prolactin (PRL), a pleiotropic hormone, has many functions
in the brain, such as maternal behavior, neurogenesis, and neuronal plasticity, among …

The role of prolactin in central nervous system inflammation

E Ramos-Martinez, I Ramos-Martínez… - Reviews in the …, 2021 - degruyter.com
Prolactin has been shown to favor both the activation and suppression of the microglia and
astrocytes, as well as the release of inflammatory and anti-inflammatory cytokines. Prolactin …

Prolactin function and putative expression in the brain

EA Cabrera-Reyes, O Limón-Morales… - Endocrine, 2017 - Springer
Introduction Prolactin is a peptide hormone mainly synthetized and secreted by the anterior
pituitary gland, but also by extrapituitary tissues, such as mammary gland, decidua, prostate …

Biomarker of neuroinflammation in Parkinson's disease

TW Liu, CM Chen, KH Chang - International journal of molecular sciences, 2022 - mdpi.com
Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …

The noradrenergic system in Parkinson's disease

E Paredes-Rodriguez, S Vegas-Suarez… - Frontiers in …, 2020 - frontiersin.org
Nowadays it is well accepted that in Parkinson's disease (PD), the neurodegenerative
process occurs in stages and that damage to other areas precedes the neuronal loss in the …

Prolactin in inflammatory response

ALP Suarez, G López-Rincón, PA Martínez Neri… - Recent advances in …, 2015 - Springer
Prolactin (PRL) is a peptide hormone produced by the pituitary gland and diverse
extrapituitary sites, which triggers activation of various signaling pathways after binding to its …

Prolactin mediates neuroprotection against excitotoxicity in primary cell cultures of hippocampal neurons via its receptor

E Vergara-Castañeda, DR Grattan… - Brain research, 2016 - Elsevier
Recently it has been reported that prolactin (PRL) exerts a neuroprotective effect against
excitotoxicity in hippocampus in the rat in vivo models. However, the exact mechanism by …

Neurodegeneration and inflammation—an interesting interplay in Parkinson's disease

C Marogianni, M Sokratous, E Dardiotis… - International journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder, caused by, so far, unknown
pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated …