Clinical outcome measures in multiple sclerosis: a review

H Inojosa, D Schriefer, T Ziemssen - Autoimmunity reviews, 2020 - Elsevier
A proper clinical evaluation of patients with Multiple Sclerosis (MS) is of great importance to
detect MS progression. It provides important data for physicians on their daily practice as …

Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in …

S Meyer-Moock, YS Feng, M Maeurer, FW Dippel… - BMC neurology, 2014 - Springer
Background There are a number of instruments that describe severity and progression of
multiple sclerosis and they are increasingly used as endpoints to assess the effectiveness of …

Disease steps in multiple sclerosis: a longitudinal study comparing disease steps and EDSS to evaluate disease progression

MJ Hohol, EJ Orav, HL Weiner - Multiple Sclerosis Journal, 1999 - journals.sagepub.com
Clinical assessment of outcome in Multiple Sclerosis (MS) patients is problematic since the
disease can affect different aspects of the central nervous system and follow a variable …

Multiple sclerosis: assessment of disability and disability scales

AJ Thompson, JC Hobart - Journal of neurology, 1998 - Springer
Attempting to measure the impact of multiple sclerosis (MS) on the individuals patients has
become a major issue stimulated by both the emergence of new therapeutic agents and the …

The Multiple Sclerosis Functional Composite measure (MSFC): an integrated approach to MS clinical outcome assessment

JS Fischer, RA Rudick, GR Cutter… - Multiple Sclerosis …, 1999 - journals.sagepub.com
Clinical outcome assessment in Multiple Sclerosis (MS) is challenging due to the diversity
and fluctuating nature of MS symptoms. Traditional clinical scales such as the EDSS are …

Correlations between multiple sclerosis functional composite, expanded disability status scale and health-related quality of life during and after treatment of relapses …

S Ozakbas, I Cagiran, B Ormeci, E Idiman - Journal of the neurological …, 2004 - Elsevier
The measurement of the clinical manifestations of multiple sclerosis (MS) is difficult. In the
present study, we examined the changes in measurement of functions during and after pulse …

Disability status and quality of life in multiple sclerosis: non-linearity of the Expanded Disability Status Scale (EDSS)

S Twork, S Wiesmeth, M Spindler, M Wirtz… - Health and quality of life …, 2010 - Springer
Background Progression in disability as measured by increase in the Expanded Disability
Status Scale (EDSS) is commonly used as outcome variable in clinical trials concerning …

Assessing long-term prognosis improvement as a consequence of treatment pattern changes in MS

R Capra, C Cordioli, S Rasia, F Gallo… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Objective: To assess whether the age at which multiple sclerosis (MS) patients reach
Expanded Disability Status Scale (EDSS) milestones changed as long as new drugs for the …

Possible clinical outcome measures for clinical trials in patients with multiple sclerosis

MD Goldman, RW Motl… - Therapeutic advances in …, 2010 - journals.sagepub.com
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease with both
clinical and pathological heterogeneity. The complexity of the MS population has offered …

'Hidden'factors influencing quality of life in patients with multiple sclerosis

AP Lysandropoulos, E Havrdova - European journal of …, 2015 - Wiley Online Library
Traditional outcome measures for patients with multiple sclerosis (MS), whether in clinical
trials or clinical practice, are currently in question. The combination of relapses, physical …