Sodium acetate abates lead-induced sexual dysfunction by upregulating testosterone-dependent eNOS/NO/cGMP signaling and activating Nrf2/HO-1 in male Wistar …

EE Besong, PJ Ashonibare, TM Akhigbe… - Naunyn-Schmiedeberg's …, 2024 - Springer
Oxidative stress has been linked with lead toxicity, including lead-induced sexual
dysfunction. On the contrary, sodium acetate has been proven to exert antioxidant activity …

Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats

EE Besong, TM Akhigbe, PJ Ashonibare… - Redox …, 2023 - Taylor & Francis
Aim: The present study evaluated the effect of lead exposure with and without zinc therapy
on male sexual and erectile function. Methods: Twenty male Wistar rats were randomly …

Lead acetate may cause erectile dysfunction by modulating NO/cGMP pathway in rat corpus cavernosum

AM Senbel, MM Helmy - Cell biology and toxicology, 2013 - Springer
Despite the fact that metal toxicity has been widely reported in industrial toxicological
studies, very little has been reported about the effect of lead exposure on erectile function …

Naringenin alleviate reproductive toxicity evoked by lead acetate via attenuation of sperm profile and biochemical alterations in male Wistar rat: Involvement of TGFβ …

AA Elhemiely, R Yahia, AM Gad - Journal of Biochemical and …, 2023 - Wiley Online Library
Exposure to Lead‐causes testicular dysfunction through oxidative stress, inflammation, and
apoptosis; however, naringenin (NGN) therapeutic impact against lead‐evoked testicular …

[HTML][HTML] Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF-κB …

ZM Zhao, S Mei, QY Zheng, J Wang, YR Yin… - Ecotoxicology and …, 2023 - Elsevier
Lead (Pb) acts as an environmental endocrine disruptor and has negative effects in animals;
excessive accumulation of lead causes reproductive dysfunction in male animals. Oxidative …

[PDF][PDF] The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model

AMS Gomaa, NS Abou Khalil… - Gen Physiol …, 2017 - scholar.archive.org
There is an increasing concern over male reproductive toxicity caused by lead exposure.
Folic acid (FA) is supposed to be a promising therapeutic strategy against lead toxicity …

Zinc improves sexual and erectile function in HAART-treated rats via the upregulation of erectogenic enzymes and maintenance of redox balance

RE Akhigbe, MA Hamed, AF Odetayo, TM Akhigbe… - The Aging …, 2023 - Taylor & Francis
Purpose HAART has been shown to impair sexual function and penile erection via
perturbation of penile redox balance, while zinc has been established to exert antioxidant …

[HTML][HTML] Effects of lead acetate on testicular function and caspase-3 expression with respect to the protective effect of cinnamon in albino rats

RAR Elgawish, HMA Abdelrazek - Toxicology Reports, 2014 - Elsevier
The aim of this study was to investigate the protective effects of cinnamon on lead acetate
induced reproductive toxicities in rats. Thirty-two male rats were randomly divided into 4 …

The protective effect of epigallocatechin-3-gallate on testicular oxidative stress in lead-induced toxicity mediated by Cyp19 gene/estradiol level

E Hassan, K Kahilo, T Kamal, M Hassan, MS Elgawish - Toxicology, 2019 - Elsevier
Exposure to heavy metals contributes to most of the unexplained male infertility. Lead (Pb) is
a well-known heavy metal, which disrupt the male reproductive system. This study was …

Ferulic acid prevents lead‐induced testicular oxidative stress and suppressed spermatogenesis in rats

P Hasanein, F Fazeli, M Parviz, M Roghani - Andrologia, 2018 - Wiley Online Library
Lead affects multiple organ systems including testis. We investigated the effects of ferulic
acid (FA) on lead‐induced oxidative stress and spermatogenesis suppression in rats …